Cerebrospinal Fluid Disorders

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However, the latter possibility is not in line with above mentioned structural change in the brain, which is unlikely to ascribe to transient increase of fibrinogen. Future longitudinal or follow up measurement of CSF fibrinogen should bring to resolve this debate. In the present study, subjects were not fasted prior to lumbar punctures. In addition, sampling time was not constant and most patients were medicated.

In conclusion, we identified, for the first time, a subpopulation of patients with MDD that showed increased CSF fibrinogen levels and white matter tract degeneration; these patients may represent a subtype of MDD. The increased fibrinogen levels might have caused axonal damage and subsequent depressive disorder.

Future clinical and basic research studies are warranted to elucidate the mechanisms underlying the elevated CSF fibrinogen in a portion of patients with MDD and to develop a new treatment option. Patients were recruited at the National Center of Neurology and Psychiatry Hospital, Tokyo, Japan, and through our website announcement. Control subjects were recruited from the community through advertisements in a free local magazine and our website announcement. All participants underwent a structured interview using the Mini-International Neuropsychiatric Interview M.

I , Japanese version 36 , 37 , administered by trained psychologists or psychiatrists. I, additional unstructured interviews, and information from medical records. Participants were excluded if they had a history of central nervous system disease, severe head injury, or substance abuse. Antidepressants doses were converted to imipramine-equivalent doses This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of the National Center of Neurology and Psychiatry, Japan.

Written informed consent was obtained from all participants. Simultaneously, blood samples were collected by venipuncture and plasma samples were obtained by centrifugation. Workers at SomaLogic Inc. Boulder, CO who were blind to the diagnosis, performed the proteomic assessments as described elsewhere 41 , The assay consists of equilibrium binding of fluorophore-tagged SOMAmers and proteins in CSF and automated partitioning steps to capture only the SOMAmers that are in complexes with their cognate proteins.

The assay transforms the measurement of proteins into the measurement of the corresponding SOMAmers DNA via hybridization to an antisense probe array.

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Protein concentrations were reported in relative fluorescence units RFU. Samples were diluted to for the CSF and for the plasma using the diluent attached to the kit. Wuhan, China and CSF samples were diluted to using phosphate buffered saline. MRI was performed on a Magnetom Symphony 1.

Cerebrospinal Fluid Conditions - Columbia Neurosurgery

High spatial resolution, 3-dimensional 3D T1-weighted images, diffusion tensor imaging DTI , conventional T2-weighted images, and fluid attenuation inversion recovery images of the brain were obtained for the morphometric study. Detailed information on MRI parameters are described elsewhere On conventional MRI, no abnormal findings were detected in the brain of any subject. A fractional anisotropy FA threshold of 0.

Evaluation of the leukoaraiosis was performed on T2-weighted images using Fazekas Scale by a single person M.


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We prepared three MDD and age-, sex- matched control sample sets. There were no significant differences in age, sex, sampling time, cell number, or total protein levels between the diagnostic groups for the two CSF sample sets. There was no overlap of subjects between the first and second samples, while 70 subjects overlapped between the CSF second and the blood fibrinogen samples.

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How to cite this article : Hattori, K. Increased cerebrospinal fluid fibrinogen in major depressive disorder.

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Gillihan, S. J Clin Psychiatry 72 , — Molendijk, M. Mol Psychiatry 19 , — Raison, C. Is depression an inflammatory disorder? Curr Psychiatry Rep 13 , — Dowlati, Y. A meta-analysis of cytokines in major depression. Biol Psychiatry 67 , — Valkanova, V. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord , — Ogawa, S. Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis. J Clin Psychiatry 75 , e—e Lopez-Duran, N. Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: a meta-analysis.

Psychoneuroendocrinology 34 , — Kunugi, H. Neuropsychopharmacology 31 , — Wang, C. Blennow, K. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6 , — Sasayama, D.


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Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. J Psychiatr Res 47 , — Maes, M.

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Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs. Psychiatry Res 66 , 1—11 Panagiotakos, D. Eur Heart J 25 , — Kop, W. Am J Cardiol 89 , — Wium-Andersen, M. Association between elevated plasma fibrinogen and psychological distress, and depression in 73, individuals from the general population. Mol Psychiatry 18 , — Elevated plasma fibrinogen, psychological distress, antidepressant use, and hospitalization with depression: two large population-based studies.

Psychoneuroendocrinology 38 , — Baune, B. The role of the inflammatory markers ferritin, transferrin and fibrinogen in the relationship between major depression and cardiovascular disorders - The German Health Interview and Examination Survey. Acta Psychiatr Scand , — Doulalas, A. Association of depressive symptoms with coagulation factors in young healthy individuals. Atherosclerosis , — Matthews, K. Psychosom Med 69 , — Von Kanel, R.

Association between longitudinal changes in depressive symptoms and plasma fibrinogen levels in school teachers. Psychophysiology 46 , — Maresca, G. Measuring plasma fibrinogen to predict stroke and myocardial infarction: an update. Arterioscler Thromb Vasc Biol 19 , — Bielak, L. All rights reserved. Skip Navigation. I Want To I Want to Find Research Faculty Enter the last name, specialty or keyword for your search below. Apply for Admission M. Fellowship Programs. Already a Patient?

Researchers showed that motility of those cilia is essential to the formation of Reissner fiber, composed of SCO-Spondin protein aggregates, described more than one century ago but which functions were little-studied.


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  • The study of a model carrying a mutation on the gene coding for SCO-Spondin, causing either a complete loss of the protein or a modification in its structure, showed a disruption in the formation of Reissner fibers. In humans, this pathology is characterized by unexplained, sudden and progressive development of spine deformations and affects 0.

    A signal in the CSF could be an avenue of research towards a better understanding of juvenile scoliosis.

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