Prostaglandins and Leukotrienes in Gastrointestinal Diseases

Free download. Book file PDF easily for everyone and every device. You can download and read online Prostaglandins and Leukotrienes in Gastrointestinal Diseases file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Prostaglandins and Leukotrienes in Gastrointestinal Diseases book. Happy reading Prostaglandins and Leukotrienes in Gastrointestinal Diseases Bookeveryone. Download file Free Book PDF Prostaglandins and Leukotrienes in Gastrointestinal Diseases at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. It's free to register here to get Book file PDF Prostaglandins and Leukotrienes in Gastrointestinal Diseases Pocket Guide.

Relation to activation of the renin--angiotensin system and hyponatremia. Pharmacological interactions between prostacyclin and thromboxanes. Br Med Bull. Mechanisms of hemostasis and therapy of thrombosis: new concepts based on the metabolism of arachidonic acid by platelets and endothelial cells. Adv Pharmacol Chemother. Hemostasis, thrombosis, and thromboembolic disorders. The role of arachidonic acid metabolites in platelet-vessel wall interactions. Eicosanoids and the blood vessel wall. Effect of cholesterol on production of thromboxane b2 by platelets in vitro.

Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med. Stimulation of vascular smooth muscle cell prostacyclin and prostaglandin E2 synthesis by plasma high and low density lipoproteins. Circ Res. Cigarette smoking inhibits prostacyclin formation. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. Platelets, carotids, and coronaries.

Critique on antithrombotic role of antiplatelet agents, exercise, and certain diets. Am J Med. Aspirin as an antithrombotic medication. Arachidonate metabolism in vascular disorders. Prostaglandins and prostaglandin inhibitors in ischemic heart disease. Clinical potential of prostacyclin. Adv Prostaglandin Thromboxane Leukot Res.

Platelet protection and heparin sparing with prostacyclin during regular dialysis therapy. Prostacyclin to prevent platelet activation during charcoal haemoperfusion in fulminant hepatic failure. A double blind study of prostacyclin in cardiopulmonary bypass surgery. Br J Haematol. Successful therapy of advanced arteriosclerosis obliterans with prostacyclin. Treatment of ischaemic stroke with prostacyclin.

  • Leukotriene;
  • Prostaglandins, Thromboxanes and Leukotrienes in Clinical Medicine!
  • how to kiss: 50 tips on how to kiss!

Treatment of Raynaud's phenomenon by intravenous infusion of prostacyclin PGI2. Br J Dermatol. Epoprostenol prostacyclin and severe arterial disease. A double-blind trial. Intermittent epoprostenol prostacyclin infusion in patients with Raynaud's syndrome. A double-blind controlled trial. A randomized, placebo controlled trial of prostacyclin PGI2 in peripheral arterial disease. Thromb Res. Regulation of the immune response by prostaglandins.

J Clin Immunol. The release of leukotriene B4 during experimental inflammation. Prostaglandins and their regulation in rheumatoid inflammation. Ann N Y Acad Sci. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. Role of prostaglandin endoperoxide PGG2 in inflammatory processes. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen interleukin A mechanism for the increased degradation of muscle proteins during fever.

Mediators of fever and muscle proteolysis. Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells. The release of leukotriene B4-like material in biologically active amounts from the lesional skin of patients with psoriasis. J Invest Dermatol. Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.

Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. Increased production of prostaglandin D2 in patients with systemic mastocytosis.

Control of lymphokine secretion by prostaglandins. Immunologic effects of nonsteroidal anti-inflammatory drugs. Prostaglandins in reproductive processes. The measurement of E and hydroxy E prostaglandins in human seminal plasma. The relation between fertility and prostaglandin content of seminal fluid in man. Fertil Steril. Inhibition of ovulation in rabbits by intrafollicular injection of indomethacin and prostaglandin F antiserum.

Life Sci. The effects of an inhibitor of prostaglandin synthesis indomethacin on ovulation, pregnancy, and pseudopregnancy in the rabbit. Aspects concerning the role of prostaglandins for ovarian function. Acta Obstet Gynecol Scand Suppl. Potent bronchoconstrictor activity of keto prostaglandin F2alpha. Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha. Physiol Rev. Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea. Annu Rev Pharmacol Toxicol. Prostaglandins and the non-pregnant uterus.

The pathophysiology of primary dysmenorrhea. Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea. Outcome trials reviewed. Am J Obstet Gynecol. Reduction of menstrual blood-loss by prostaglandin-synthetase inhibitors. Endogenous prostaglandin synthesis and abortion. A mini-review.

Induction of abortion by prostaglandins in the second trimester of pregnancy. A review. Response of pregnant human uterus to prostaglandin-F2-alpha-induction of labour. Br Med J. Labor induction with prostaglandins. Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation. Semin Perinatol. Oestrogens, prostaglandins, and cervical ripening. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. Pharmacologic closure of patent ductus arteriosus in the premature infant.

Pharmacologic use of prostaglandin E1 in infant with congenital heart disease. Am Heart J. Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age.

Pediatr Res. Prostaglandins, renal function and vascular regulation.

Arachidonic Acid & Eicosanoids

Prostaglandins and the kidney. Am J Nephrol. Arachidonic acid metabolism, prostaglandins and the kidney. Renal syndromes associated with nonsteroidal antiinflammatory drugs. Renal effects of prostaglandins and clinical adverse effects of nonsteroidal anti-inflammatory agents. Medicine Baltimore May; 63 3 — Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin.

Kidney Int. Role of prostaglandins in the pathogenesis of Bartter's syndrome. Regulation of urinary prostaglandins in Bartter's syndrome. Evidence for a prostaglandin-independent defect in chloride reabsorption in the loop of Henle as a proximal cause of Bartter's syncrome. The effect of indomethacin on plasma renin activity in man under normal conditions and after stimulation of the renin angiotensin system.

Metabolic mimicry of Bartter's syndrome by covert vomiting: utility of urinary chloride determinations. Effect of indomethacin and prostaglandin A1 on renal function and plasma renin activity in alcoholic liver disease. Prostaglandins: modulators of renal function and pressor resistance in chronic liver disease. J Clin Endocrinol Metab. Functional renal alterations in chronic liver diseases. Interrelationship between prostaglandins and renin release. Role of prostaglandins in renin secretion. Role of renal prostaglandins in the control of renin release.

Evidence for a direct stimulatory effect of prostacyclin on renin release in man. The effect of sodium restriction and prostaglandin inhibition on the renin-angiotensin system in man. Aspirin triggers previously unrecognized bioactive eicosanoids in human endothelial cell-leukocyte interactions. The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, prostaglandin metabolism in cyclooxygenase knockout mice. Gastroenterology : 94—, The apology of a second-class man. Annu Rev Physiol 47 : 1—15, Why the stomach does not digest itself.

Sci Am : 87—93, Aspirin induces a rapid up-regulation of cyclooxygenase-2 expression in the rat stomach. Aliment Pharmacol Ther 11 : —, Oxygen free radicals interact with indomethacin to cause gastrointestinal injury. Agents Actions 17 : —, A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in the rat. Bacterial colonization and healing of gastric ulcers: the effects of epidermal growth factor.


Gastric ulcer perforation, associated with the use of injectable ketorolac. Ann Pharmacother 27 : 42—43, Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 87 : —, Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.

The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. Cyclooxygenasederived lipoxin A 4 increases gastric resistance to aspirin-induced damage. Gastrointestinal safety of NO-aspirin NCX in healthy human volunteers: a proof of concept endoscopic study. Interaction of COX-2 inhibitor with aspirin and NO-aspirin in the human gastric mucosa: evidence for a protective role of nitric oxide.

Coxibs and cardiovascular disease. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol 4-acetamidophenol.

  1. Cinq, six bonheurs (Petite Poche) (French Edition);
  2. Educar las emociones (Spanish Edition).
  3. Educating Ariadne, Part 2: Exploration and Submission.
  4. Vagabonds (The End Series Book 2).
  5. Intestinal mucins in health and disease. Digestion 17 : —, Digestion 56 : —, Mucosal acid causes gastric mucosal microcirculatory disturbance in nonsteroidal anti-inflammatory drug-treated rats. Eur J Pharmacol : 53—59, Focal gastric mucosal blood flow in aspirin-induced ulceration. Ann Surg : —, Gastric mucosal protective mechanisms: roles of epithelial bicarbonate and mucus secretions. Scand J Gastroenterol 19 Suppl 79—86, Influence of gastric acidity on bacterial and parasitic enteric infections.

    A perspective. Ann Int Med 78 : —, Interaction of indomethacin and naproxen with gastric surface-active phospholipids: a possible mechanism for the gastric toxicity of nonsteroidal anti-inflammatory drugs NSAIDs. Biochem Pharmacol 57 : —, Dig Dis Sci 40 : —, Does aspirin damage canine gastric mucosa by reducing its surface hydrophobicity? Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucous gel. Gastroenterology 98 : —, Experimental model of ischemic bowel necrosis.

    Am J Pathol : —, Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole. Nonsteroidal anti-inflammatory effect of sulindac sulfoxide and sulfide on gastric mucosa. Clin Pharmacol Ther 38 : 65—70, Influence of gastric pH on gastric and jejunal flora. Gut 8 : —, Effect of acid and pepsin on blood coagulation and platelet aggregation.

    A possible contributor prolonged gastroduodenal mucosal hemorrhage. Gastroenterology 74 : 38—43, Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge. Br J Pharmacol : —, Inhibition by prostaglandins of leukotriene B 4 release from activated neutrophils. Cell loss from normal and stressed gastric mucosae of the rat. Gastroenterology 72 : —, Prostaglandin E 2 aggravates gastric mucosal injury induced by histamine in rats through EP1 receptors.

    Life Sci 74 : —, Leukotriene formation by human polymorphonuclear leukocytes from endogenous arachidonate. Physiological triggers and modulation by prostanoids. Biochem Pharmacol 38 : —, Gastrointestinal safety of AZD, a cyclooxygenase inhibiting nitric oxide donator: proof of concept study in humans.

    Gut 52 : —, Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Aspirin-induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis. Br J Clin Pharmacol 32 : 77—83, Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology 10 : —, Gastric mucosal barrier, hydrophobic lining to the lumen of the stomach.

    Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ : —, Dig Dis Sci 49 : —, Prostaglandins inhibit inflammatory mediator release from rat mast cells. Role of prostaglandins in regulation of gastric mucosal blood flow and acid secretion. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology 91 : —, Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury.

    Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Enhanced gastric mucosal leukotriene B 4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 34 : —, Restorative impact of rabeprazole on gastric mucus and mucin production impairment during naproxen administration: its potential clinical significance.

    Dig Dis Sci 50 : —, Acid transport through channels in the mucous layer of rat stomach. Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine. Pediatr Res 62 : —, Effect of 16,dimethyl prostaglandin E 2 on lipidic organelles of rat gastric surface mucous cells.

    Dual action of prostaglandin E 2 on gastric acid secretion through different EP-receptor subtypes in the rat. Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology 93 : —, Stimulation by a hypertonic environment in vitro. Prostaglandins 15 : —, Prostaglandin E receptor EP1 subtype but not prostacyclin IP receptor involved in mucosal blood flow response of mouse stomachs following barrier disruption. Digestion 67 : —, Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol : —, J Pharmacol Exp Ther : —, Arachidonic acid metabolites regulate interleukin-1 production.

    Biochem Biophys Res Commun : —, Prostaglandins as endogenous mediators of interleukin 1 production. J Immunol : —, Regulation of macrophage tumor necrosis factor production by prostaglandin E 2. Phosphatidylcholine-associated aspirin accelerates healing of gastric ulcers in rats. Dig Dis Sci 43 : —, Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 51 : —, Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis.

    Approaches to non-steroidal anti-inflammatory drug use in the high-risk patient. Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

    Cell 83 : —, Effect of indomethacin on basal and histamine-stimulated human gastric acid secretion. Gut 25 : —, Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion. Anti-inflammatory and gastrointestinal sparing activity of a novel H 2 S-releasing diclofenac agent: new insights into the biological roles of H 2 S.

    Free Radical Biol Med 42 : —, The hydrophobic barrier properties of gastrointestinal mucus. Annu Rev Physiol 57 , —, Phosphatidylcholine association increases the anti-inflammatory and analgesic activity of ibuprofen in acute and chronic rodent models of joint inflammation: relationship to alterations in bioavailability and cyclooxygenase-inhibitory potency. Nat Med 1 : —, NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes.

    J Pharm Pharmacol 58 : —, Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in the rat. Gastroenterology 84 : —, Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion.

    Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: shifting the angiogenic balance. Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release.

    The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract. Gut 47 : —, Endothelium-derived relaxing factor nitric oxide has protective actions in the stomach. Life Sci 45 : —, Selective cyclooxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1 : —, Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp Biol Med : —, Annexin-1 modulates gastric mucosal healing.

    Prostaglandins and Leukotrienes in Gastrointestinal Diseases | SpringerLink

    Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections? Eur J Surg Suppl : 89—99, Relative roles of acid and mucosal compression in ulcerogenesis in indomethacin-insulin-treated rat. Dig Dis Sci 33 : —, Nitric oxide and mucosal defense: a little goes a long way. Cyclooxygenaseregulated vascular endothelial growth factor release in gastric fibroblasts. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. The roles of ethanol and of acid in the production of gastric mucosal erosions in rats.

    Virchows Arch B Cell Pathol 38 : 23—38, A functional model for extracellular gastric mucus in the rat. Virchows Arch B Cell Pathol 46 : —, Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Involvement of prostaglandin E receptor EP2 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach. J Physiol Pharmacol 58 : —, Ablation of capsaicin sensitive afferent nerves impairs defense but not rapid repair of rat gastric mucosa. Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, tensin signaling.

    Life Sci 69 : —, Prostaglandin E 2 synthesis and secretion: the role of PGE 2 synthases. Clin Immunol : —, Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A 4 receptor. Nature Med 8 : —, Prostaglandins and prostaglandin metabolites in human gastric juice.

    Prostaglandins 20 : —, On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Biochim Biophys Acta : —, The importance of mucus layers and bicarbonate transport in preservation of gastric juxtamucosal pH. Relationship of gastric mucosal damage induced in pigs by anti-inflammatory drugs to their effects on prostaglandin production. Dig Dis Sci 27 : —, Microvascular injury during gastric mucosal damage by anti-inflammatory drugs in pigs and rats. Agents Actions 13 : —, Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation.

    Cytoprotection by prostaglandins in rats. Intravenous, oral and intrajejunal administration. Gastroenterology 70 : —, Potent ulcerogenic actions of platelet-activating factor on the stomach. Nature : 54—56, The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart. The nitric oxide-releasing naproxen derivative displays cardioprotection in perfused rabbit heart submitted to ischemia-reperfusion. Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.

    Membrane prostaglandin E synthase a novel therapeutic target. Pharmacol Rev 59 : —, Nature : 51—54, Gut 35 : —, Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Comparison of the COX-inhibiting nitric oxide donator AZD and rofecoxib in treating the signs and symptoms of osteoarthritis of the knee. Arthritis Rheum 53 : —, Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage.

    Am J Med 86 : —, Gastric mucus of the guinea pig: proton carrier and diffusion barrier. Ueber penetrierende magen- und jejunalgeschwure. Beitr Klin Chir 67 : 96—, Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. Resolution of inflammation: state of the art, definitions and terms.

    COX-1 and 2, intestinal integrity, pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA : —, The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis.

    Scand J Gastroenterol 30 : —, Am J Gastroenterol 89 : —, Gastritis increases resistance to aspirin-induced mucosal injury via COXmediated lipoxin synthesis. Prostaglandin E receptors. J Biol Chem : —, Prostaglandin E inhibitors indomethacin-induced gastric lesions through EP-1 receptors. Digestion 63 : 92—, Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF.

    EP4 receptor mediation of prostaglandin E 2 -stimulated mucus secretion by rabbit gastric epithelial cells. Biochem Pharmacol 58 : —, Aspirin-triggered epi-lipoxin A 4 LXA 4 and LXA 4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med : —, J Physiol Pharmacol 57 : —, Curr Top Med Chem 5 : —, Effect of S 1- 5-chloro 4-fluorophenyoxy benzamido ethyl benzoic acid CJ , a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa.

    Role of prostaglandins in maintaining gastric mucus-cell permeability against acid exposure. J Lab Clin Med : 52—58, Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal anti-inflammatory drugs. J Physiol 95 : 21—27, Google Scholar Tarnawski A. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Prostaglandin protection of human isolated gastric glands against indomethacin and ethanol injury. Evidence for direct cellular action of prostaglandin. J Clin Invest 81 : —, Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans.

    Gut 46 : —, Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats. Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 16 : —, Role of oxygen-derived free radicals in indomethacin-induced gastric injury.

    Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol : —, On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals prostaglandin and vesiglandin. J Physiol 88 : —, Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28 : —, Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Fundam Clin Pharmacol 17 : 11—20, The cellular and molecular basis of gastric mucosal defense.

    Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. Can J Physiol Pharmacol 71 : —, The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal anti-inflammatory drugs and endothelin. Gastroenterology 99 : —, Role of prostanoids in the protective actions of BWC on the gastric mucosa. Eur J Pharmacol : 45—52, Prevention of endotoxin-induced gastrointestinal damage by CV, an antagonist of platelet-activating factor.

    Role of mucus in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents. Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants.

    What is Kobo Super Points?

    Prostaglandins 31 : —, A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Cyclooxygenase-1 contributes to inflammatory responses in rats and mice: implications for GI toxicity. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulphide-releasing diclofenac derivative in the rat.

    Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor. Hydrogen sulfide enhances ulcer healing. Platelet-activating factor mediates gastric damage induced by hemorrhagic shock. Potential cardioprotective actions of no-releasing aspirin. Nat Rev Drug Discov 1 : —, Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: anti-inflammatory without gastropathy.

    NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Reduction by cytoprotective agents of ethanol-induced damage to the rat gastric mucosa: a correlated morphological and physiological study. Can J Physiol Pharmacol 60 : —, A diclofenac derivative without ulcerogenic properties.

    Prostaglandins and Rheumatoid Arthritis

    Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. The treatment of Helicobacter pylori infection in the management of peptic ulcer disease. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

    Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80 : 94—98, Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate.

    Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99 : —, Scand J Gastroenterol 41 : —, Role of mucosal cell renewal in mucosal protection in the gastrointestinal tract. New York: Raven, , p. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature : 82—85, Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

    Molecular determinants of aspirin-induced neutrophil adherence to endothelial cells. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. Annexin-1 mediates the gastroprotective effects of dexamethasone against indomethacin. Previous Back to Top. Figures References Related Information Cited By The polysaccharide-rich tea of Ximenia americana barks prevents indomethacin-induced gastrointestinal damage via neutrophil inhibition.

    Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers? A comparison of short-term outcomes between laparoscopic and open emergent repair of perforated peptic ulcers. Protective Effects of Methanol Extract of Vernonia amygdalina del. Beneficial effects of the commercial lactic acid bacteria product, Vigiis , on gastric mucosa and intestinal bacterial flora in rats. Microbiota—drug interactions: Impact on metabolism and efficacy of therapeutics.

    Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions. Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. PubMed Abstract. Huang, C. JPEN J. Enteral Nutr. Hull, M. Trials 14, Ibrahim, A.

    Nutrition 28, — Ichihara, H. Therapeutic effects of cationic hybrid liposomes on the hepatic metastasis of colon carcinoma along with apoptosis in vivo. Jia, H. Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. John, S. Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study.

    Jordan, A. Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil 5-FU on growth of the colon cancer cell line Caco Kaplan, G. The global burden of IBD: from to Khanna, R. Safety of infliximab for the treatment of inflammatory bowel disease: current understanding of the potential for serious adverse events. Expert Opin. Drug Saf. Kodentsova, V. Kostic, A. The microbiome in inflammatory bowel disease: current status and the future ahead.

    Lawson, L. Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Lev-Tzion, R. Omega 3 fatty acids fish oil for maintenance of remission in Crohn's disease. Cochrane Database Syst. Li, F. Lubiprostone is effective in the treatment of chronic idiopathic constipation and irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Mayo Clin. Maderna, P. Lipoxins: resolutionary road. Maskrey, B. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. Food Res. Masoodi, M. Meister, D. Effect of fish oil enriched enteral diet on inflammatory bowel disease tissues in organ culture : Differential effects on ulcerative colitis and Crohn's disease. Meyer, L. Michalak, A.

    Common links between metabolic syndrome and inflammatory bowel disease: current overview and future perspectives. Minihane, A. Low-grade inflammation, diet composition and health: current research evidence and its translation. Mocellin, M. A systematic review and meta-analysis of the n-3 polyunsaturated fatty acids effects on inflammatory markers in colorectal cancer.

    Lipids 48, — Morin, C. Prostaglandins, leukotrienes and essential fatty acids anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. Prostaglandins Leukot. Acids 89, — Mosinska, P. Inhibition of ileal bile acid transporter: an emerging therapeutic strategy for chronic idiopathic constipation. Novel investigational drugs for constipation-predominant irritable bowel syndrome: a review. Drugs 25, 1— Mozaffari, S. Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome.

    Drug Metab. Musso, G. Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Drug Discov. Nakamoto, K. Yakugaku Zasshi , — Nielsen, A. Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. Okada-Iwabu, M. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature , — Palsson, O. Park, J. Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer. Powell, W. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids HETEs and oxoeicosatetraenoic acids oxo-ETEs derived from arachidonic acid.

    Rangel-Huerta, O. Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials. Rashvand, S. Dietary fatty acid intakes are related to the risk of ulcerative colitis: a case-control study. Colorectal Dis. Romano, C. Roy, J. Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: bioactive drugs?

    Biochimie , 56— Salaga, M. Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice. Naunyn Schmiedebergs. Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase FAAH. Crohn's Colitis 8, — Inhibition of fatty acid amide hydrolase FAAH as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract.

    Sala-Vila, A. The effect of three lipid emulsions differing in fatty acid composition on growth, apoptosis and cell cycle arrest in the HT colorectal cancer cell line. Sanson, M. Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats. Schaubeck, M. Reciprocal interaction of diet and microbiome in inflammatory bowel diseases. Scheiffele, F. Induction of TNBS colitis in mice. Chapter 15, Unit Seinder, D. An oral supplement enriched with fish oil, soluble fiber, and ontioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial.

    Serhan, C. Pro-resolving lipid mediators are leads for resolution physiology. Nature , 92— Shailubhai, K. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis basic study.

    Shen, X. Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta-analysis of data from individuals. Shinohara, M. Novel endogenous proresolving molecules:essential fatty acid-derived and gaseous mediators in the resolution of inflammation. Silva, J. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. Sioen, I. Dietary intake and food sources of total and individual polyunsaturated fatty acids in the Belgian population over 15 years old.

    Sobczak, M. Pharmacological Reports Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases. Solakivi, T. Scandinavian journal of gastroenterology serum fatty acid profile in subjects with irritable bowel syndrome serum fatty acid profile in subjects with irritable bowel syndrome.

    Prostaglandins, Thromboxanes and Leukotrienes in Clinical Medicine

    Solem, C. Treatment patterns, symptom reduction, quality of life, and resource use associated with lubiprostone in irritable bowel syndrome constipation subtype. Sorensen, L. Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial.

    Nutrients 6, — Stenson, W. The universe of arachidonic acid metabolites in inflammatory bowel disease: can we tell the good from the bad? Sweetser, S. Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome? Tanaka, Y. Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis. Teixeira, M. Primary prevention of colorectal cancer: myth or reality?

    Trebble, T. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Turner, D. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids fish oil : a systematic review and meta-analyses. Tyagi, A. Dietary marine n-3 PUFAs do not affect stress-induced visceral hypersensitivity in a rat maternal separation model.

    Vasudevan, A. Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer. Cancer Prev. Viladomiu, M. Nutritional protective mechanisms against gut inflammation. West, N. Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut 59, — Wilson, A. Quality of life in managed care patients with irritable bowel syndrome. Care Interface 17, 24—28, Xu, X.

    Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis. Yan, G. Lipidome in colorectal cancer. Ye, Y. The epidemiology and risk factors of inflammatory bowel disease. Nutritional modulation of non-alcoholic fatty liver disease and insulin resistance.

    Zhang, C. Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway. Zhang, P. Role of serum polyunsaturated fatty acids in the development of colorectal cancer.