A new study reveals a developmental basis for mitral valve prolapse, caused by altered primary cilia-mediated regulation of extracellular matrix deposition during development, and suggests that mutations in primary cilia genes can be the cause of mitral valve prolapse in some patients.
In Brief 14 June Comment 13 June These forces are realigning academic medicine and traditional industrial partners, and also creating the context for an emerging new ecosystem for discovery, translation, care and implementation that promises to transform and integrate all these areas of endeavour. Fred Hutchinson Cancer Research Center.
Parkring 12a, , Vienna, Austria. Advanced search. Skip to main content. Summersby Circadian rhythms and the molecular clock In cardiovascular biology and disease. Article series Epidemiology of cardiovascular disease An ongoing Series of articles describing the global epidemiology of CVD. Focus issue Cardiovascular ageing Five expert Reviews on mechanisms and prevention of age-related changes to the heart and vasculature. Focus issue Cardiac development and regeneration Eight Reviews covering major topics in heart development, repair and regeneration.
Search Nature Reviews Cardiology. Latest Reviews Review Article 27 June Permanent His bundle pacing: shaping the future of physiological ventricular pacing By stimulating the His—Purkinje network directly, His bundle pacing results in synchronized, physiological ventricular activation, which might improve clinical outcomes compared with the use of right ventricular apical pacing. Review Article 26 June Role of aspirin in primary prevention of cardiovascular disease The role of aspirin for the primary prevention of cardiovascular disease is controversial.
Review Article 26 June Vascular smooth muscle cells in atherosclerosis In this Review, Mallat and colleagues critically evaluate the studies on the origin, fate and functions of vascular smooth muscle cells VSMCs in atherosclerosis, highlighting the importance of developmental origin, clonal expansion and plasticity of VSMCs cells in atherosclerosis and summarizing the roles of VSMCs and VSMC-derived cells in plaque development and progression. Review Article 13 June The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies Neuromodulation therapy might be clinically useful in the management and prevention of lethal arrhythmias.
Review Article 11 June RNA-based diagnostic and therapeutic strategies for cardiovascular disease With the increase in the availability of RNA screening tools, numerous non-coding RNAs with important functions in the heart have been identified. More Reviews More Reviews. Research Highlight 17 June Cilia defects linked to mitral valve prolapse A new study reveals a developmental basis for mitral valve prolapse, caused by altered primary cilia-mediated regulation of extracellular matrix deposition during development, and suggests that mutations in primary cilia genes can be the cause of mitral valve prolapse in some patients.
Heart Failure Fact Sheet
Irene Fernandez-Ruiz. More Collections. Trending Altmetric Tricuspid valve disease: diagnosis, prognosis and management of a rapidly evolving field. Role of aspirin in primary prevention of cardiovascular disease.
complete medical guide and prevention for heart disease volume xiv heart failure Manual
Vascular smooth muscle cells in atherosclerosis. RNA-based diagnostic and therapeutic strategies for cardiovascular disease. Share This. Unhealthy eating and physical inactivity are leading causes of death in the U. Heart Disease , 2. Cancer , 3.
Chronic lower respiratory disease , 4. Cerebrovascular disease stroke and related conditions , 5. Unintentional injuries accidents , 6.
Diabetes mellitus 73, 8. Influenza and pneumonia 50, 9. Nephritis, nephrotic syndrome and nephrosis kidney disease 45, Yet unhealthy eating habits and physical inactivity are leading causes of loss of independence: Diabetes is a leading cause of blindness and amputations. Roughly 73, people have lower-limb amputations each year due to diabetes. Even just a slight fracture in these areas can result in loss of independence.
Those who survive often require long-term nursing home care. Ogden C, Carrol M. Childhood Obesity Facts ,. Department of Health and Human Services.
SYMPTOMS & SIGNS
Dietary Guidelines for Americans Government Printing Office, December National Diabetes Statistics Report, National Osteoporosis Foundation. What Is Osteoporosis?
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Atlanta, GA: U. Adults: National Health Interview Survey, Vital Health Stat , vol. Child Trends Data Bank. Cawley J, et al.
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